Leucine-Induced Upregulation of Terminal Oligopyrimidine mRNA Translation in Skeletal Muscle: Just the Tip of the Iceberg?
نویسنده
چکیده
n BIOCHEMICAL, MOLECULAR, AND GENETIC MECHANISMS Leucine Differentially Regulates Gene-Specific Translation in Mouse Skeletal Muscle Micah J Drummond, Paul T Reidy, Lisa M Baird, Brian K Dalley, and Michael T Howard 1616 See corresponding commentary on page 1603. Perinatal Brain Docosahexaenoic Acid Concentration Has a Lasting Impact on Cognition in Mice Luis E Lozada, Abhishek Desai, Karl Kevala, Ji-Won Lee, and Hee-Yong Kim 1624 S-Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic b-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing b-Cell Function in Male Mice Hiroko Horiuchi, Atsuko Usami, Rie Shirai, Naoki Harada, Shinichi Ikushiro, Toshiyuki Sakaki, Yoshihisa Nakano, Hiroshi Inui, and Ryoichi Yamaji 1631
منابع مشابه
تاثیر یک دوره تمرین مقاومتی بر بیان اینترلوکین-6 و RCAN-1 در عضله اسکلتی موشهای صحرایی دیابتی شده با استروپتوزوسین
Background: Myokines released from skeletal muscle have multiple metabolic and hypertrophic effects. On the other hand, one of proposed pathways for effects of exercise training on metabolic diseases is calcineurin signaling pathway. With considering to relation between interleukin-6 (IL-6) and calcineurin, the purpose of this study was to investigate whether the resistance training has an effe...
متن کاملبررسی تاثیر یک جلسه فعالیت مقاومتی بر بیان ژن های NT-4/5 و p75 در عضلات سریع و آهسته موش های صحرایی
Background and purpose: Activity-dependent expression of neurotrophins in skeletal muscle is not well established. In this research we aimed at studying the effect of one session resistance exercise on mRNA expression of NT4.5 and P75 proteins in slow and fast skeletal muscles of Wistar rats. Materials and methods: Sixteen male Wistar rats (10 wk of age) were housed at room temperature under a...
متن کاملThe Response of Skeletal Muscle-Expressed Neurotrophins to Acute Resistance Exercise in Male Wistar Rats
Background. BDNF and NT-4/5 have been proposed to be involved in the coordinated adaptations of the neuromuscular system to the elevated level of activity, but an activity-dependent expression of neurotrophins in skeletal muscle is not well established. Objectives. We, therefore, investigated the effect of one session of resistance exercise on mRNA expression of some neurotrophins in Slow and ...
متن کاملBranched-Chain Amino Acids: Metabolism, Physiological Function, and Application Signaling Pathways and Molecular Mechanisms through which Branched-Chain Amino Acids Mediate Translational Control of Protein Synthesis
BCAAs stimulate protein synthesis in in vitro preparations of skeletal muscle. Likewise, the stimulation of protein synthesis in skeletal muscle produced by intake of a mixed meal is due largely to BCAAs. Of the three BCAAs, leucine is the one primarily responsible for the stimulation of protein synthesis under these circumstances. The stimulatory effect of leucine on protein synthesis is media...
متن کاملAmino Acids: Regulation of Global and Specific mRNA Translation
Maintenance of optimal rates of protein synthesis in both liver and skeletal muscle requires a continuous supply of essential amino acids is a prerequisite for. Deprivation of even a single essential amino acid causes a decrease in the synthesis of essentially all cellular proteins through an inhibition of the initiation phase of mRNA translation. However, the synthesis of all proteins is not r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of nutrition
دوره 147 9 شماره
صفحات -
تاریخ انتشار 2017